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翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Genome survey sequence ： ウィキペディア英語版 Genome survey sequence In the fields of bioinformatics and computational biology, Genome Survey Sequences (GSS) are nucleotide sequences similar to EST's that the only difference is that most of them are genomic in origin, rather than mRNA.〔(GenBank Flat File 96.0 Release Notes )〕 Genome Survey Sequences are typically generated and submitted to NCBI by labs performing genome sequencing and are used, amongst other things, as a framework for the mapping and sequencing of genome size pieces included in the standard GenBank divisions.〔(GenBank Flat File 96.0 Release Notes )〕 ==Contributions== Genome survey sequencing is a new way to map the genome sequences since it is not dependent on mRNA. Current genome sequencing approaches are mostly high-throughput shotgun methods, and GSS is often used on the first step of sequencing. GSSs can provide an initial global view of a genome, which includes both coding and non-coding DNA and contain repetitive section of the genome unlike ESTs. For the estimation of repetitive sequences, GSS plays an important role in the early assessment of a sequencing project since these data can affect the assessment of sequences coverage, library quality and the construction process.〔Otto, Thomas D., et al. "ReRep: Computational detection of repetitive sequences in genome survey sequences (GSS)." Bmc Bioinformatics 9.1 (2008): 366.〕 For example, in the estimation of dog genome, it can estimate the global parameters, such as neutral mutation rate and repeat content.〔Kirkness, Ewen F., et al. "The dog genome: survey sequencing and comparative analysis." Science 301.5641 (2003): 1898-1903.〕 GSS is also an effective way to large-scale and rapidly characterizing genomes of related species where there is only little gene sequences or maps.〔Venkatesh, Byrappa, et al. "Survey sequencing and comparative analysis of the elephant shark (Callorhinchus milii) genome." PLoS biology 5.4 (2007): e101.〕 GSS with low coverage can generate abundant information of gene content and putative regulatory elements of comparative species.〔Hitte, Christophe, et al. "Facilitating genome navigation: survey sequencing and dense radiation-hybrid gene mapping." Nature Reviews Genetics 6.8 (2005): 643-648.〕 It can compare these genes of related species to find out relatively expanded or contracted families. And combined with physical clone coverage, researchers can navigate the genome easily and characterize the specific genomic section by more extensive sequencing.〔Kirkness, Ewen F., et al. "The dog genome: survey sequencing and comparative analysis." Science 301.5641 (2003): 1898-1903.〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Genome survey sequence」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.